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1 article(s) from Konyariková, Zuzana

Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2

Marek Baráth,
Jana Jakubčinová,
Zuzana Konyariková,
Stanislav Kozmon,
Katarína Mikušová and
Maroš Bella

Beilstein J. Org. Chem. 2020, 16, 1853–1862, doi:10.3762/bjoc.16.152

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Figure 1: Target ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones 1‒3.

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Figure 2: Molecular representation of the best binding poses of the four compounds with the predicted highest...

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Scheme 1: Reagents and conditions: a) 1. (BnO)₂P-NMe₂, 1H-tetrazole, 0 °C→rt, 1 h, 2. m-CPBA, 0 °C→rt, 1.5‒2 ...

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Scheme 2: Reagents and conditions: a) PivCl, pyridine, CH₂Cl₂, rt, overnight; b) BnBr, NaOH, TBAB, THF, reflu...

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Scheme 3: Reagents and conditions: a) EtSH, BF₃∙OEt₂, CH₂Cl₂, 0 °C, 2 h; b) 1. (BnO)₂P-NMe₂, 1H-tetrazole, 0 ...

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Scheme 4: Reagents and conditions: a) PhSH, or iPrSH, BF₃·OEt₂, CH₂Cl₂, −5 °C, 1 h; b) BF₃·OEt₂, Ac₂O, 0 °C, ...

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Scheme 5: Reagents and conditions: a) 1. (BnO)₂P-NMe₂, 1H-tetrazole, 0 °C→rt, 1 h, 2. m-CPBA, 0 °C→rt, 1.5‒2 ...

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Figure 3: TLC analysis of the effects of the target compounds at 500 μM on the production of lower lipid-link...

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Figure 4: TLC analysis of the dose effects of the compounds 1bα and 3a on production of lower lipid-linked ga...

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Published 27 Jul 2020

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